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EFFICACY OF PLACENTAL EXTRACT IN ORAL SUBMUCOUS FIBROSIS: A CLINICAL STUDY

EFFICACY OF PLACENTAL EXTRACT IN ORAL SUBMUCOUS FIBROSIS: A CLINICAL STUDY

Author: DR. AMBER KESARWANI*, AND DR. RAJESH KUMAR**,

*Postgraduate Resident, Department of ENT [IMS] BHU, Varanasi (U.P.) India. e-Mail : dramber.kesar@gmail.com **Associate Professor, Department of ENT [IMS] BHU, Varanasi (U.P.) India.

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Abstract
Aims: Oral submucous fibrosis (OSMF) is well known potentially malignant condition of unknown aetiology mostly seen in people of Asian descent. This clinical trial was done to evaluate the effectiveness of Placental extract in OSMF and study of its side effects. Materials and Methodology: This clinical trial was done in Department of E.N.T., I.M.S.-B.H.U. on 60 patients which were divided in two groups. Group I consists of 30 patients who were given Inj. Placental extract 2ml.weekly for 10 weeks while Group II included 30 patients which served as Control group (age and sex matched) who were given multivitamins. All the patients were asked to quit substance abuse and were taught jaw dilator exercises. Follow up record was done monthly up to 6 months of beginning of treatment. Observations and Results: Significant improvement in patients receiving Inj. Placental extract was observed. Total improvement in symptoms score is 88.8% after 6 months of treatment in Group I while in Group II it was just 47.7% (p<0.05). The trismus improved by 6.7 mm in group I and 1.6 mm in group II (p<0.05). Conclusion: Placental extract is quite effective in alleviating symptoms and signs of OSMF from the preliminary data. No significant side effects were noted. A follow up study is required to assess long term outcome of this therapy.
Keywords: Oral Submucous Fibrosis, Placental extract, Trismus

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